Microsoft's latest Patch Tuesday includes over 50 security updates, addressing six actively exploited zero-day vulnerabilities. Notable flaws include NTFS vulnerabilities (CVE-2025-24991, CVE-2025-24993, CVE-2025-24984) that allow memory disclosure, local code execution, or data leakage through malicious virtual hard disks or USB drives. Additionally, CVE-2025-24983, exploited via the PipeMagic backdoor, affects older Windows versions, while CVE-2025-26633 targets the Microsoft Management Console through malicious files. Organizations should prioritize patching, especially on older or unsupported systems, and enforce strict endpoint security and monitoring to mitigate the risks.